CERVICAL SPONDYLOLISTHESIS
Subaxial Subluxation | Degenerative Instability | Myelopathy Risk
Etiological Classification
Critical Must-Knows
- Translation over 3.5mm or angulation over 11 degrees indicates instability on flexion-extension radiographs.
- Degenerative spondylolisthesis most common at C4-C5 and C5-C6 (maximum motion segments).
- Myelopathy develops when canal diameter under 13mm or cord compression on MRI.
- ACDF (anterior cervical discectomy and fusion) is gold standard for single-level degenerative subluxation.
- Bilateral facet dislocation = complete disruption of ALL ligaments = surgical emergency.
Examiner's Pearls
- "White-Panjabi criteria: 3.5mm translation or 11 degrees angulation = instability
- "Degenerative subluxation: anterior (anterolisthesis) from facet incompetence
- "Traumatic dislocation: high-energy hyperflexion injury - bilateral facet fracture-dislocation
- "Post-laminectomy kyphosis: iatrogenic from facet disruption during decompression
Clinical Imaging
Imaging Gallery


Critical Cervical Spondylolisthesis Exam Points
Instability Criteria
White-Panjabi: Translation over 3.5mm or angle over 11 degrees. Measured on lateral flexion-extension radiographs. Indicates ligamentous failure requiring fusion.
Myelopathy Threshold
Canal diameter under 13mm or cord signal change. Sagittal canal narrowing causes myelopathy. MRI shows T2 hyperintensity in cord = myelomalacia.
Traumatic Urgency
Bilateral facet dislocation = surgical emergency. Complete ligamentous disruption with high cord injury risk. Requires urgent closed reduction then fusion.
Surgical Goal
Restore alignment and achieve solid fusion. ACDF for degenerative. Posterior fusion if post-laminectomy. Combined anterior-posterior if severe deformity.
Quick Decision Guide
| Clinical Scenario | Imaging | Treatment | Key Pearl |
|---|---|---|---|
| Degenerative, neck pain only | C4-C5 anterolisthesis 2mm, no canal stenosis | Conservative: PT, collar for flares, NSAIDs | Under 3.5mm without cord compression - trial conservative |
| Degenerative with radiculopathy | C5-C6 subluxation 4mm, foraminal stenosis | C5-C6 ACDF | Translation over 3.5mm = instability, ACDF restores alignment |
| Myelopathy, canal stenosis | C4-C5 subluxation, canal 11mm, cord signal | Urgent ACDF or corpectomy with fusion | Canal under 13mm + myelopathy = urgent decompression |
| Bilateral facet dislocation | C6-C7 locked facets, cord compression | Closed reduction MUA, then posterior fusion | Surgical emergency - reduce within 8 hours if cord injury |
ANGELWhite-Panjabi Instability Criteria
Memory Hook:ANGEL criteria = Angulation and Translation thresholds define ligamentous instability!
LOCKEDTraumatic Bilateral Facet Dislocation Features
Memory Hook:Facets are LOCKED = complete ligamentous disruption requiring urgent reduction!
SMITHACDF Surgical Pearls
Memory Hook:SMITH = Standard anterior cervical fusion technique named after Smith-Robinson!
Overview and Epidemiology
Cervical spondylolisthesis is forward (anterolisthesis) or backward (retrolisthesis) displacement of one cervical vertebra on another. Unlike lumbar spondylolisthesis (often isthmic), cervical subluxation is predominantly degenerative (facet and disc degeneration) or traumatic (bilateral facet dislocation from hyperflexion injury).
Epidemiology:
- Degenerative: Most common at C4-C5 and C5-C6 (maximum motion), age 50-70, gradual onset
- Traumatic: Bilateral facet dislocation from MVA, diving injuries (high cervical) - complete ligamentous disruption
- Iatrogenic: Post-laminectomy kyphosis from excessive facet resection (over 50%)
- Gender: Degenerative cases slight female predominance (2:1)
Clinical Impact:
- Radiculopathy: 40% have nerve root compression from foraminal stenosis
- Myelopathy: 15-20% develop cord compression if canal under 13mm
- Instability: Progressive subluxation if ligamentous failure (over 3.5mm translation)
Anatomy
Spinal Cord Vulnerability
The cervical spinal cord occupies 40-50% of canal diameter. Normal sagittal canal diameter is 17-18mm. Stenosis under 13mm causes cord compression. Under 10mm causes severe myelopathy. Degenerative subluxation narrows canal anteriorly (disc-osteophyte complex) and posteriorly (ligamentum flavum buckling).
Cervical Stability
Stabilizing structures (anterior to posterior):
- Anterior longitudinal ligament (ALL): Limits extension, resists anterior translation
- Intervertebral disc: Axial load distribution, limits rotation
- Posterior longitudinal ligament (PLL): Limits flexion, reinforces posterior disc
- Facet capsules: Resist flexion, rotation, translation (critical for stability)
- Ligamentum flavum: Elastic, prevents buckling into canal
- Interspinous/supraspinous ligaments: Limit flexion
Pathophysiology
Degenerative Pathophysiology
Degenerative cervical spondylolisthesis follows a predictable cascade:
- Disc degeneration initiation: Age-related proteoglycan loss leads to decreased disc height and load-sharing capacity
- Facet joint overload: Reduced disc height transfers axial load posteriorly to facet joints
- Facet arthropathy: Cartilage erosion, synovitis, and capsular laxity develop
- Osteophyte formation: Marginal osteophytes form at disc margins and uncovertebral joints
- Ligamentous failure: Chronic facet capsule incompetence allows segmental translation
- Progressive subluxation: Anterior translation progresses as facets fail to resist shear forces
Traumatic Pathophysiology
Hyperflexion Mechanism
- Force vector: Forward deceleration (MVA, diving)
- Structure failure sequence: Posterior ligaments → facet capsules → disc → ALL
- Facet dislocation: Inferior facet of superior vertebra jumps anterior to superior facet of inferior vertebra
- "Perched" facets: Partial dislocation where facet tips are aligned
- "Locked" facets: Complete dislocation with facet interlocking
Cord Injury Mechanisms
- Direct compression: Posterior vertebral body edge compresses cord
- Vascular injury: Anterior spinal artery compression causes ischemia
- Contusion: Cord contusion from rapid displacement
- Severity: Bilateral facet dislocation = 60-80% neurologic deficit
- ASIA Grade A: Complete injury, under 5% recovery chance
Neurologic Sequelae
The cervical spinal cord is vulnerable in spondylolisthesis through:
- Dynamic stenosis: Flexion narrows canal anteriorly, extension narrows posteriorly
- Static stenosis: Canal diameter under 13mm causes chronic cord compression
- Myelomalacia: Chronic compression causes irreversible T2 signal change on MRI
Classification and Measurements
White-Panjabi Instability Criteria
| Parameter | Normal | Unstable Threshold | Clinical Implication |
|---|---|---|---|
| Sagittal translation | Under 3.5mm | Over 3.5mm on flexion-extension | Ligamentous failure (facet capsule, PLL) |
| Sagittal angulation | Under 11 degrees | Over 11 degrees between adjacent levels | Facet and disc incompetence |
| Canal diameter | Over 13mm | Under 13mm | High myelopathy risk |
Measured on lateral flexion-extension radiographs. Change over 3.5mm or 11 degrees between flexion and extension indicates instability.
Clinical Presentation
History
- Neck pain: Axial pain worse with movement (degenerative)
- Radiculopathy: Arm pain, dermatomal paresthesias (foraminal stenosis)
- Myelopathy: Hand clumsiness, gait imbalance, Lhermitte sign
- Trauma history: MVA, diving, fall if traumatic dislocation
Examination
- Range of motion: Reduced flexion-extension, pain at extremes
- Spurling test: Radiculopathy if foraminal stenosis
- Myelopathy signs: Hyperreflexia, Hoffmann, Babinski, gait ataxia, inverted radial reflex
- Neurologic level: Sensory/motor deficit corresponds to compressed nerve root or cord
Myelopathy Red Flags
Progressive cervical myelopathy is insidious: hand clumsiness (difficulty with buttons, writing), gait instability (wide-based), bowel/bladder urgency. Once established, myelopathy may not fully reverse. Urgent surgical decompression if cord signal change on MRI.
Investigations
Imaging Protocol
Lateral C-spine: Neutral, flexion, extension. Measure: Anterior translation, sagittal angle change. White-Panjabi thresholds (3.5mm, 11 degrees). AP: Alignment, spinous process deviation.
Facet joints: Fracture, arthritis, subluxation. Canal diameter: Sagittal measurement. Trauma: Detect occult fractures missed on XR.
Cord compression: Degree and level. T2 signal change: Hyperintensity = myelomalacia (poor prognosis). Foraminal stenosis: Nerve root compression. Disc herniation: Contribution to canal stenosis.

Measuring Translation on Lateral Radiograph
Draw lines along posterior vertebral body cortex of superior and inferior vertebrae. Measure horizontal distance between lines. Over 3.5mm = pathological translation. Compare flexion and extension views - dynamic instability if difference over 3.5mm.
Management Algorithm

Conservative Management
Indications: Translation under 3.5mm, no myelopathy, minimal radiculopathy, patient preference.
Conservative Protocol
NSAIDs: Naproxen 500mg BD. Collar: Soft collar for comfort (under 2 weeks - avoid prolonged use). Activity modification: Avoid extreme flexion-extension.
Physiotherapy: Gentle ROM, avoid forceful manipulation. Strengthening: Deep neck flexors, scapular stabilizers. Ergonomics: Neutral cervical posture.
Repeat imaging: Flexion-extension XR if symptoms worsen. Surgical threshold: Progressive translation, new neuro signs, refractory pain.
Surgical Technique
Anterior Cervical Discectomy and Fusion
ACDF Steps
Supine, shoulder roll, neck extension. Right-sided approach (avoids recurrent laryngeal nerve injury - RLN courses in tracheoesophageal groove on left).
Transverse skin incision at disc level. Blunt dissection between sternocleidomastoid laterally and strap muscles medially. Retract carotid sheath laterally, esophagus/trachea medially. Identify disc by needle localization and fluoroscopy.
Remove disc with rongeurs, curettes. Decompress anterior spinal canal (remove posterior osteophytes, PLL if cord compression). Uncovertebral joints: Decompress bilaterally for foraminal stenosis.
Endplate preparation: Remove cartilage to bleeding bone. Cage insertion: PEEK or titanium cage packed with bone graft. Plate fixation: Anterior cervical plate with screws into vertebral bodies (prevents subsidence).
Avoiding RLN Injury
Recurrent laryngeal nerve risk 1-2%. Higher on left side (RLN loops around aortic arch). Use right-sided approach when possible. Avoid excessive medial retraction of trachea/esophagus. Neuromonitoring can detect RLN at risk.
Complications
| Complication | Incidence | Management |
|---|---|---|
| Dysphagia (ACDF) | 10-15% transient | Usually resolves 6-12 weeks, speech therapy if persistent |
| RLN injury (ACDF) | 1-2% | Hoarse voice, vocal cord medialization if permanent |
| Pseudarthrosis (ACDF) | 5% single level, 15% multilevel | Revision ACDF with bone graft |
| C5 palsy (posterior) | 5-10% | Deltoid/biceps weakness, usually recovers over 6 months |
| Subsidence (ACDF) | 10-15% | Cage sinks into endplate - plate prevents progression |
Evidence Base and Key Trials
ACDF for Cervical Spondylolisthesis Outcomes
- ACDF for single-level degenerative subluxation: 95% fusion rate
- 85% good-excellent outcome for radiculopathy
- 70% improvement for myelopathy (better if cord signal normal)
- Cage + plate superior to allograft alone (lower pseudarthrosis)
White-Panjabi Cervical Instability Criteria
- Translation over 3.5mm = ligamentous failure
- Angulation over 11 degrees = facet incompetence
- Validated in cadaveric and clinical studies
- Widely used threshold for surgical decision-making
Bilateral Facet Dislocation Outcomes and Timing
- 75 patients with bilateral facet dislocation reviewed
- Early reduction (under 8 hours) associated with improved neurologic outcomes
- MRI prior to reduction identifies herniated disc in 10-15%
- Closed reduction successful in 75% of awake, cooperative patients
ACDF vs Posterior Fusion for Multilevel Cervical Disease
- Compared anterior vs posterior approaches for multilevel cervical pathology
- ACDF fusion rate 92% at 2 years for single level, 78% for multilevel
- Posterior laminoplasty preserves motion but higher C5 palsy rate (5-10%)
- Combined anterior-posterior for severe deformity achieves 95-98% fusion
Exam Viva Scenarios
Practice these scenarios to excel in your viva examination
Scenario 1: Degenerative Subluxation with Radiculopathy
"A 60-year-old presents with 6 months of progressive right arm pain radiating to thumb and index finger. Examination shows 4/5 biceps weakness, reduced biceps reflex, and positive Spurling sign. Flexion-extension radiographs show C5-C6 anterolisthesis of 4mm. MRI shows C5-C6 disc herniation and foraminal stenosis compressing C6 nerve root. How do you manage?"
Scenario 2: Bilateral Facet Dislocation
"A 25-year-old presents after diving accident. He has complete C6 motor and sensory level with absent lower limb reflexes (spinal shock). Lateral C-spine shows C6-C7 bilateral facet dislocation with 60% anterior translation. How do you manage acutely?"
MCQ Practice Points
White-Panjabi Translation Question
Q: What sagittal translation threshold indicates cervical instability? A: Over 3.5mm on lateral flexion-extension radiographs. Measured between adjacent vertebral bodies. Indicates ligamentous failure (facet capsule, PLL).
Angulation Threshold Question
Q: What angular change between adjacent cervical vertebrae indicates instability? A: Over 11 degrees on flexion-extension radiographs. Measured as sagittal plane angle change between superior and inferior endplates.
Most Common Level Question
Q: What is the most common level for degenerative cervical spondylolisthesis? A: C4-C5 and C5-C6 - these are maximum motion segments in the cervical spine, subject to highest biomechanical stress.
Bilateral Facet Dislocation Question
Q: What imaging finding confirms bilateral facet dislocation? A: Naked facet sign on lateral XR - inferior facet of superior vertebra is anterior to superior facet of inferior vertebra. Translation typically over 50% vertebral body width.
Spinal Cord Injury Risk
Q: What degree of translation is associated with complete spinal cord injury? A: Over 50% vertebral body width (bilateral facet dislocation). Unilateral facet dislocation (25-50% translation) has incomplete injury risk. Translation under 25% rarely causes cord injury.
MRI Pre-Reduction Controversy
Q: When is MRI indicated before closed reduction of cervical dislocation? A: Controversial - traditionally if patient is obtunded/unexaminable. However, newer evidence (Vaccaro study) supports early closed reduction in awake patients regardless of MRI, as traction injury from delay may exceed disc herniation risk.
CERVICAL SPONDYLOLISTHESIS
High-Yield Exam Summary
Instability Criteria
- •White-Panjabi: Translation over 3.5mm or angle over 11 degrees
- •Measured on lateral flexion-extension radiographs
- •Canal diameter under 13mm = high myelopathy risk
- •Bilateral facet dislocation = complete ligament disruption
Common Levels
- •Degenerative: C4-C5 and C5-C6 (maximum motion)
- •Traumatic BFD: C5-C6 and C6-C7
- •Post-laminectomy: any level with over 50% facet resection
- •Meyerding grade: I (0-25%), II (25-50%), III (50-75%), IV (75-100%)
Surgical Indications
- •Myelopathy with cord compression (MRI T2 signal change)
- •Translation over 3.5mm or angle over 11 degrees with symptoms
- •Progressive neurologic deficit despite conservative management
- •Bilateral facet dislocation (trauma) = surgical emergency
ACDF Technique
- •Right-sided Smith-Robinson approach (avoid RLN on left)
- •Complete discectomy, posterior osteophyte removal
- •Decompress uncovertebral joints for foraminal stenosis
- •PEEK cage + autograft + anterior plate (prevents subsidence)
Complications
- •Dysphagia 10-15% (transient, resolves 6-12 weeks)
- •RLN injury 1-2% (hoarse voice, higher left-sided approach)
- •Pseudarthrosis 5% single level, 15% multilevel
- •C5 palsy 5-10% (posterior approach, deltoid/biceps weakness)
