OPLL (Ossification of Posterior Longitudinal Ligament)
Hyperostosis of the Ligament Causing Stenosis | Prevalence in East Asian Populations
OPLL Classification (Tsuyama)
Critical Must-Knows
- OPLL is a genetic disorder of heterotopic ossification (COL6A1, COL11A2 genes).
- Strongly associated with DISH (Diffuse Idiopathic Skeletal Hyperostosis).
- The 'Double Layer Sign' on CT suggests Dural Ossification (High risk of CSF leak).
- The 'K-Line' (Kyphosis Line) determines if Posterior Surgery (Laminoplasty) is viable.
- Major risk of surgery is C5 Palsy and Dural Tear.
Examiner's Pearls
- "Always look for the 'Double Layer Sign' on CT before attempting Anterior Surgery.
- "If K-Line is NEGATIVE (Ossification crosses line), Laminoplasty will FAIL (Need Fusion or Corpectomy).
- "Beware of 'Floating Island' technique for dural adherence.
- "Differential: AS (Ankylosing Spondylitis) - but AS affects discs/annulus, OPLL affects ligament.
Critical Surgical Decisions
At a Glance
Surgical Approach Selection
| Factor | Anterior (Corpectomy/ACDF) | Posterior (Laminoplasty) | Posterior (Laminectomy + Fusion) |
|---|---|---|---|
| K-Line Status | Can treat K-Line (-) | Requires K-Line (+) | Can treat K-Line (-) if corrected |
| Dural Tear Risk | High (10-30%) | Low (less than 1%) | Low (less than 1%) |
| Decompression | Direct (Removes mass) | Indirect (Drift back) | Indirect + Realignment |
| C5 Palsy Risk | Low | Moderate | High |
Mnemonics
JAPANOPLL Associations
Memory Hook:Key demographic factors.
SCMLTypes of OPLL
Memory Hook:Classification system.
DOUBLECT Signs of Risk
Memory Hook:Surgical danger signs.
Overview and Epidemiology
Definition OPLL is a hyperostotic condition characterized by calcification and ossification of the posterior longitudinal ligament. It results in spinal canal stenosis and myelopathy.
Etiology
- Genetic: Strong familial inheritance. Associated with collagen genes (COL11A2, COL6A1).
- Metabolic: Associated with Diabetes (NIDDM), Obesity, and DISH.
- Mechanical: Stress on the ligament may trigger osteogenesis.
Pathology
- Begins as hypertrophy of the ligament.
- Progresses to cartilaginous proliferation.
- Ends in enchondral ossification.
- Can penetrate the dura mater ("Dural Ossification"), making surgical separation impossible without dural resection.
Pathophysiology and Anatomy
The Posterior Longitudinal Ligament (PLL)
- Runs along the posterior aspect of the vertebral bodies (within the canal).
- Acts to prevent hyperflexion.
- In OPLL, it becomes a space-occupying lesion anterior to the cord.
The K-Line (Kyphosis Line)
- A virtual line drawn on a lateral Neutral X-ray.
- Start: Midpoint of C2 Spinal Canal.
- End: Midpoint of C7 Spinal Canal.
- Significance: Defines the anterior limit of the spinal canal.
- K-Line Positive: The OPLL mass lies ANTERIOR to the line. (Good for posterior surgery).
- K-Line Negative: The OPLL mass CROSSES the line. (Posterior surgery will fail as cord cannot drift back past the mass).
Classification Systems
Tsuyama Classification (Based on Lateral X-ray/CT)
- Continuous Type (27%): A long lesion extending over several vertebrae. Most difficult to treat.
- Segmental Type (39%): Lesions located behind each vertebral body, not crossing the disc. (Safest for ACDF/Corpectomy as discs are clear).
- Mixed Type (29%): Combination of above. Most common.
- Localized Type (5%): Circumscribed lesion at disc level.
Clinical Assessment
Presentation
- Similar to CSM but often more severe/rapid once symptomatic.
- Myelopathy: Hands (clumsy), Gait (ataxic), Bladder (late).
- Radiculopathy: Can occur if lateral extension involves roots.
- Trauma: Acute quadriplegia after minor fall is a classic presentation (stiff spine + stenosis).
Examination
- UMN signs (Hyperreflexia, Clonus, Hoffman's).
- Limited ROM (Stiff neck - often has DISH).
DISH Co-morbidity
50% of OPLL patients have DISH. Check the rest of the spine (Thoracic/Lumbar) for ankylosis. Rigid spines are prone to "Chalk stick fractures".
Imaging and Investigations
Workup Protocol
- Mandatory for OPLL. MRI allows visualization but CT defines the bony anatomy.
- Assess:
- Thickness of ossification (greater than 50% canal occupancy = bad prognosis).
- Shape (Beak/Hill/Mushroom).
- Double Layer Sign (Dural involvement).
- T2 Signal: Check for myelomalacia.
- Effacement: CSF signal loss.
- Lateral: Draw the K-Line. Measure C2-C7 angle.
- Flex/Ext: Usually stiff, but check for instability.
Management Algorithm

Non-Operative Management
Observation
- Many patients have OPLL incidentally.
- Progression rate is slow but steady.
- Contraindications to observation: Progressive myelopathy (mJOA score dropping), acute onset.
- Advice: Avoid contact sports, fall prevention, collar for comfort only.
Surgical Technique
Laminoplasty (Preferred)
- Indication: Multilevel OPLL (C3-C7) with K-Line (+).
- Rationale: Expanding the canal posteriorly allows the cord to "drift back" away from the anterior OPLL mass.
- Technique: "Open Door" (Hirabayashi) or "French Door" (Kurokawa).
- Plate Fixation: Use mini-plates to keep the lamina open.
- Advantages: Preserves motion (vs fusion), lower complication rate than anterior.
- Risks: C5 palsy (tethering from drift back), Axial neck pain.
Step-by-Step (Double Door / French Door):
- Positioning: Prone, Mayfield head clamp. Neck flexed slightly (military tuck).
- Exposure: Midline approach. Subperiosteal dissection to the lateral masses. Preserve the Semispinalis Cervicis attachment to C2 (reduces post-op kyphosis/pain).
- Spinous Process: Removed.
- Troughs:
- Midline Trough: Created through the junction of the lamina (roof). Full thickness cut.
- Lateral Troughs: Created at the lamina-facet junction bilaterally. Thin the outer cortex but leave the inner cortex intact (Greenstick fracture).
- Opening: The split lamina are opened like a book ("French Door") laterally.
- Fixation: Ceramic spacers or mini-plates bridge the gap and hold the door open.
- Closure: Deep closure over a drain.
Complications
| Complication | Ant Rate | Post Rate | Management |
|---|---|---|---|
| CSF Leak | High (20%) | Low | Lumbar drain, bed rest, fibrin glue. Do NOT repair primarily (tissue too thin). |
| C5 Palsy | 5% | 10-15% | Observation. Usually recovers. Due to 'tethering' effect. |
| Progression | Low | Medium | OPLL can grow post-surgery. Laminoplasty allows continued growth. |
| Implant Failure | High (Corpectomy) | Low | Use supplemental posterior fixation for multilevel corpectomy. |
Postoperative Care
- CSF Leak Protocol: If leak suspected/confirmed: Flat bed rest 24-48hrs. Acetazolamide. Lumbar Drain if persistent.
- Collar: Aspen collar 6 weeks (especially if fusion).
- Neuro Rehab: Intensive gait training.
Outcomes and Prognosis
- Surgical Outcome: Generally good if K-Line respected.
- Recurrence: OPLL mass continues to grow in 20% of cases, especially with Laminoplasty (motion preserved). Fusion arrests growth.
- Poor Prognostic Factors:
- Diagnosis over 60 years.
- Myelopathy duration over 1 year.
- Massive canal occupancy (greater than 60%).
- Trauma-induced onset.
- High intramedullary signal intensity on T2 MRI.
- Diabetes Mellitus (Poor wound healing, infection risk).
Progression Rates:
- Longitudinal studies show OPLL grows 2mm/year in 10% of patients.
- Anterior fusion stops this growth in the fused segments, but adjacent segment disease is accelerated.
- Laminoplasty allows continued growth, but usually the canal expansion is sufficient to accommodate it.
Evidence Base
K-Line Classification
- Introduced the concept of K-Line for deciding surgical approach.
- K-Line (+) group had significantly better JOA recovery with Laminoplasty.
- K-Line (-) group had POOR results with Laminoplasty (insufficient drift back).
- Recommendation: K-Line (-) needs Anterior surgery or correcting fusion.
Prospective Multicenter Study (Japan)
- 400+ patients with OPLL.
- Anterior surgery had higher recovery rate (JOA) but higher complication rate.
- Posterior surgery safer but slightly less recovery.
- Dural tear rate in Anterior surgery: 15%.
Surgical Complications of OPLL
- Review of ossified dura management.
- Floating Island technique significantly reduces CSF leak vs resection.
- C5 palsy incidence up to 18% in posterior fusion groups.
Genetics of OPLL
- Identified 6 susceptibility loci for OPLL.
- Highlighted the role of COL6A1 and COL11A2.
- Confirmed the strong genetic component independent of obesity/diabetes.
Natural History of OPLL
- Followed 450 patients for over 10 years.
- Patients with greater than 60% canal stenosis invariably developed myelopathy.
- Trauma was the trigger in 20% of acute deteriorating cases.
- Asymptomatic patients with less than 60% stenosis rarely progressed.
Viva Scenarios
Exam Viva Scenarios
Practice these scenarios to excel in your viva examination
Dural Ossification
"You are performing an Anterior Corpectomy for OPLL. You reach the posterior cortex and drill it down. You see a white, hard layer that looks like dura but is bone. What is this and what do you do?"
K-Line Decision
"60M with C3-C7 OPLL. Myelopathic. Lateral X-ray shows the OPLL mass crosses the K-Line. Lordosis is lost. Plan?"
Post-op Deterioration
"Reviewing a post-op Laminoplasty patient on Day 1. He says he cannot lift his arms (Shoulders). Legs are fine."
MCQ Practice Points
Genetics
Q: Which gene is most strongly associated with OPLL? A: COL6A1. (Collagen Type 6).
Association
Q: What is the most common concomitant spinal disorder in OPLL patients? A: DISH (Diffuse Idiopathic Skeletal Hyperostosis). Look for flowing osteophytes.
Imaging Sign
Q: Converting continuous OPLL to segmental type surgery has what sign on CT? A: Double Layer Sign. It indicates dural ossification.
Complication
Q: What is the most common neurological complication after posterior decompression for OPLL? A: C5 Palsy.
K-Line
Q: A 'Negative K-Line' implies what deformity? A: Kyphosis. The OPLL mass sits posterior to the line connecting C2 and C7 canal midpoints.
Australian Context
Incidence
- While rare in Caucasians (0.1%), Australia has a significant Asian population where incidence approaches 2-3%.
- Should be on the differential for any Asian patient presenting with myelopathy.
WorkCover
- Often presents after minor trauma at work.
- The pre-existing condition (OPLL) is the major cause, but the trauma is the "aggravating factor".
Exam Day Cheat Sheet
OPLL Summary
High-Yield Exam Summary
Key Concepts
- •Ectopic Ossification (PLL)
- •Japanese/Asian (greater than 2%)
- •DISH Association
- •Myelopathy over Radiculopathy
Classification
- •Continuous vs Segmental
- •K-Line (+) = Laminoplasty OK
- •K-Line (-) = Anterior or Fusion
- •Double Layer Sign = Dural Tear Risk
Surgery
- •Posterior preferred (Safety)
- •Anterior (Corpectomy) for K-Line (-)
- •Floating Island Technique
- •Instrumented Fusion for Correction
Risks
- •C5 Palsy (Tethering)
- •CSF Leak (Anterior)
- •Progression (Recurrence)
- •Pseudoarthrosis
Image Manifest
- [opll-ct-sagittal-continuous.jpg]: CT sagittal showing continuous ossified strip behind bodies
- [opll-mri-t2-cord-compression.jpg]: MRI showing cord compression by low signal mass
- [opll-ct-axial-double-layer.jpg]: Axial CT showing double layer sign