Skip to main content
OrthoVellum
Knowledge Hub

Study

  • Topics
  • MCQs
  • ISAWE
  • Operative Surgery
  • Flashcards

Company

  • About Us
  • Editorial Policy
  • Contact
  • FAQ
  • Blog

Legal

  • Terms of Service
  • Privacy Policy
  • Cookie Policy
  • Medical Disclaimer
  • Copyright & DMCA
  • Refund Policy

Support

  • Help Center
  • Accessibility
  • Report an Issue
OrthoVellum

© 2026 OrthoVellum. For educational purposes only.

Not affiliated with the Royal Australasian College of Surgeons.

Spinal Cord Injury

Back to Topics
Contents
0%

Spinal Cord Injury

Comprehensive guide to spinal cord injury - ASIA classification, neurogenic shock, methylprednisolone controversy, timing of surgery, rehabilitation for orthopaedic exam

complete
Updated: 2024-12-17
High Yield Overview

SPINAL CORD INJURY

ASIA Classification | MAP 85-90 | No Steroids | Early Surgery

15KNew SCIs per year (USA)
C5Most common cervical level
85-90Target MAP mmHg
24hEarly surgery goal

ASIA IMPAIRMENT SCALE

ASIA A (Complete)
PatternNo motor/sensory below level
TreatmentPrognosis limited
ASIA B-D (Incomplete)
PatternSome preservation below
TreatmentBetter recovery potential
ASIA E (Normal)
PatternFull motor and sensory
TreatmentReturn to baseline

Critical Must-Knows

  • ASIA classification is THE standard for neurological assessment in SCI
  • MAP 85-90mmHg for 7 days improves outcomes in incomplete SCI
  • Methylprednisolone is NOT recommended (NASCIS trials flawed)
  • Early surgery (within 24h) for incomplete SCI improves outcomes
  • Complete SCI (ASIA A) has poor prognosis regardless of treatment

Examiner's Pearls

  • "
    Neurogenic shock = bradycardia + hypotension (loss of sympathetic tone)
  • "
    Spinal shock = transient areflexia, NOT hypotension
  • "
    Sacral sparing = incomplete injury (better prognosis)
  • "
    Bulbocavernosus reflex return signals end of spinal shock

Clinical Imaging

Imaging Gallery

Ex vivo1H-MRI assessments 6 weeks following two severities of spinal cord injury. MRI image of ex vivo mouse spinal cord after mid- (A–D) and high-injury severity (E–H). Note the excellent anatomical
Click to expand
Ex vivo1H-MRI assessments 6 weeks following two severities of spinal cord injury. MRI image of ex vivo mouse spinal cord after mid- (A–D) and high-injCredit: Noristani HN et al. via Front Neuroanat via Open-i (NIH) (Open Access (CC BY))
Longitudinalin vivo1H-MRI assessments of two severities of spinal cord injury in mice. (A–C)In vivo sagittal images of the same mouse that underwent a mid-severity lesion. (A) 24 h following spinal co
Click to expand
Longitudinalin vivo1H-MRI assessments of two severities of spinal cord injury in mice. (A–C)In vivo sagittal images of the same mouse that underwent aCredit: Noristani HN et al. via Front Neuroanat via Open-i (NIH) (Open Access (CC BY))
MRI images of the spinal cord in a rat model of spinal cord transection.Conventional MR T1- and T2-weighted images show that the signals at the injured spinal cord were decreased after spinal cord tra
Click to expand
MRI images of the spinal cord in a rat model of spinal cord transection.Conventional MR T1- and T2-weighted images show that the signals at the injureCredit: Zhang D et al. via Neural Regen Res via Open-i (NIH) (Open Access (CC BY))
Characteristics of lumbar intervertebral disc herniation and spinal cord injury. (A1) L4/5 disc herniation. The intervertebral disc was classified as grade IV according to magnetic resonance imaging (
Click to expand
Characteristics of lumbar intervertebral disc herniation and spinal cord injury. (A1) L4/5 disc herniation. The intervertebral disc was classified as Credit: Zhao B et al. via Int. J. Mol. Med. via Open-i (NIH) (Open Access (CC BY))

Critical Spinal Cord Injury Exam Points

ASIA Grading

American Spinal Injury Association scale from A-E. ASIA A = complete (no motor or sensory below level). ASIA B-D = incomplete (sacral sparing present). ASIA B = sensory only. ASIA C = motor less than 3. ASIA D = motor 3 or more.

Neurogenic vs Spinal Shock

Neurogenic shock = cardiovascular (hypotension + bradycardia) from loss of sympathetic tone. Spinal shock = neurological (areflexia below injury level). Spinal shock ends when bulbocavernosus reflex returns.

Methylprednisolone

No longer recommended. NASCIS II/III trials were flawed (post-hoc analysis). Guidelines now recommend AGAINST steroids in SCI. If asked in exam, know the controversy and current stance.

MAP Goals

Maintain MAP 85-90mmHg for 5-7 days in incomplete SCI. This ensures adequate spinal cord perfusion. Use vasopressors (norepinephrine) if needed. Critical for preventing secondary injury.

Quick Decision Guide

ASIA GradeDefinitionPrognosisManagement Priority
ASIA A (Complete)No motor/sensory below levelLess than 5% motor recoveryStabilization, prevent secondary injury
ASIA B (Incomplete)Sensory only, no motor50% regain walking abilityUrgent surgery if compression
ASIA C (Incomplete)Motor grade less than 375% improve one gradePriority for early decompression
ASIA D (Incomplete)Motor grade 3 or more95% maintain walkingSurgery based on instability
Mnemonic

ASIAASIA Impairment Scale

A
Absent function
Complete injury, no motor/sensory below
B
Below sensory only
Incomplete, sensory preserved
C
Cannot move well
Motor less than grade 3
D
Decent motor
Motor grade 3 or more
E
Everything normal
Full recovery

Memory Hook:ASIA A is complete and BAD prognosis. ASIA B-D are incomplete with better outcomes!

Mnemonic

SPINALSpinal Shock Signs

S
Sphincter tone absent
Loss of anal tone
P
Peripheral reflexes absent
Below injury level
I
Injury level flaccidity
No spasticity yet
N
No bulbocavernosus reflex
Initially absent
A
Areflexia below injury
Transient loss
L
Lasts 24-72 hours typically
Resolves with reflex return

Memory Hook:SPINAL shock is neurological (areflexia), NOT cardiovascular - ends when bulbocavernosus returns!

Mnemonic

MAPMAP Goals for SCI

M
Maintain blood pressure
Prevent secondary injury
A
Aim for 85-90 mmHg
Target range for 5-7 days
P
Perfuse the cord
Vasopressors if needed

Memory Hook:MAP 85-90 for 7 days prevents secondary cord injury from hypoperfusion!

Overview and Epidemiology

Definition

Spinal cord injury (SCI) is damage to the spinal cord resulting in temporary or permanent changes to motor, sensory, or autonomic function below the level of injury. The distinction between complete (ASIA A) and incomplete (ASIA B-E) injuries is crucial for prognosis.

Etiology

Mechanism of Injury:

  • Motor vehicle accidents (39%)
  • Falls (31%) - increasing in elderly
  • Violence (14%) - gunshot wounds predominant
  • Sports (8%) - diving injuries common
  • Medical/surgical complications (5%)

Level Distribution:

  • Cervical (55%) - most common, worst outcomes
  • Thoracic (30%) - high velocity injuries
  • Lumbar (15%) - often associated with burst fractures

Bimodal Age Distribution

Two peaks: Young adults (15-29 years) from trauma, and elderly (over 65 years) from falls with pre-existing cervical stenosis. The elderly population is growing as a proportion of SCI patients.

Australian Context

Australia has approximately 350-400 new traumatic SCIs per year. The Victorian Spinal Cord Service at Austin Hospital is a major referral center. Transfer protocols with retrieval services are established for early spinal cord center care.

Anatomy and Pathophysiology

Spinal Cord Anatomy

Key Anatomical Points:

  • Cord ends at L1-L2 (conus medullaris)
  • Cervical cord enlargement (C4-T1) for upper limb
  • Lumbar enlargement (L1-S2) for lower limb
  • Central grey matter (motor anterior, sensory posterior)
  • Peripheral white matter (tracts)

Spinal Cord Tracts

Major Spinal Cord Tracts

TractFunctionLocationClinical Syndrome
Corticospinal (lateral)Motor - voluntary movementLateral columnWeakness below level
Spinothalamic (lateral)Pain and temperatureAnterior-lateralContralateral loss
Dorsal columnsProprioception, vibrationPosterior columnIpsilateral loss
Autonomic tractsSympathetic/parasympatheticIntermediolateralNeurogenic shock

Pathophysiology of Injury

Primary Injury:

  • Mechanical disruption at time of trauma
  • Compression, contusion, transection
  • Not reversible

Secondary Injury (Preventable):

  • Ischemia from hypotension (target MAP 85-90)
  • Edema and inflammation
  • Excitotoxicity (glutamate release)
  • Apoptosis (programmed cell death)
  • Occurs over hours to days

Secondary Injury Prevention

The goal of acute SCI management is to prevent secondary injury. This is achieved through: MAP goal 85-90mmHg, early decompression if compressed, avoiding hypoxia, and maintaining normothermia. The primary injury is done - focus on preventing further damage.

Classification

American Spinal Injury Association Impairment Scale

The standard classification for SCI worldwide:

ASIA A - Complete:

  • No motor or sensory function in sacral segments S4-S5
  • No voluntary anal contraction
  • No perianal sensation
  • Prognosis: less than 5% regain functional ambulation

ASIA B - Incomplete (Sensory Only):

  • Sensory function preserved below level including S4-S5
  • No motor function below level
  • Prognosis: 50% regain some walking ability

ASIA C - Incomplete (Motor less than 3):

  • Motor function preserved below level
  • Half of key muscles below level have grade less than 3
  • Prognosis: 75% improve at least one ASIA grade

ASIA D - Incomplete (Motor 3 or more):

  • Motor function preserved below level
  • Half or more of key muscles grade 3 or greater
  • Prognosis: 95% maintain community ambulation

ASIA E - Normal: Full motor and sensory function. May have abnormal reflexes.

Incomplete Spinal Cord Syndromes

Central Cord Syndrome:

  • Most common incomplete pattern
  • Upper limbs worse than lower limbs
  • Usually from hyperextension with stenosis
  • Cape distribution sensory loss
  • Best prognosis of incomplete syndromes

Brown-Sequard Syndrome:

  • Hemisection of cord
  • Ipsilateral motor loss and proprioception
  • Contralateral pain and temperature loss
  • Often from penetrating trauma
  • Good prognosis for ambulation

Anterior Cord Syndrome:

  • Spared dorsal columns only
  • Motor loss complete
  • Pain and temperature lost
  • Proprioception and vibration preserved
  • Worst prognosis of incomplete syndromes

Posterior Cord Syndrome: Rare. Loss of proprioception and vibration with motor preserved. Usually from tumors or vitamin B12 deficiency.

ASIA Key Muscle Testing

10 paired myotomes tested bilaterally:

LevelMuscleAction
C5Elbow flexorsBiceps
C6Wrist extensorsECRL/ECRB
C7Elbow extensorsTriceps
C8Finger flexorsFDP to middle finger
T1Finger abductorsSmall finger abduction
L2Hip flexorsIliopsoas
L3Knee extensorsQuadriceps
L4Ankle dorsiflexorsTibialis anterior
L5Long toe extensorsEHL
S1Ankle plantarflexorsGastrocnemius

Grading 0-5 (MRC Scale): 0 = no movement, 3 = against gravity, 5 = normal.

Clinical Assessment

Primary Survey

  • Airway: C-spine controlled, may need intubation
  • Breathing: Diaphragm function (C3-5), assess respiratory
  • Circulation: Neurogenic shock? Bradycardia, hypotension
  • Disability: GCS, pupils, gross neuro
  • Exposure: Complete spine exam, log roll

ASIA Examination

  • Motor: 10 key muscles bilaterally (0-5 scale)
  • Sensory: Light touch + pinprick at 28 dermatomes
  • Sacral sparing: Perianal sensation, voluntary anal contraction
  • Reflexes: Bulbocavernosus for spinal shock
  • Document clearly: Neurological level and ASIA grade

Key Examination Findings

Neurogenic Shock:

  • Hypotension (loss of sympathetic vascular tone)
  • Bradycardia (unopposed parasympathetic to heart)
  • Warm, dry peripheries (vasodilation)
  • Occurs with lesions above T6
  • NOT the same as spinal shock

Spinal Shock:

  • Transient areflexia below injury level
  • Flaccid paralysis (even if complete injury)
  • Absent bulbocavernosus reflex initially
  • Resolves over 24-72 hours typically
  • Reflex return signals end of spinal shock

Sacral Sparing = Incomplete Injury

Always check for sacral sparing - perianal sensation and voluntary anal contraction. Any sacral function preserved means incomplete injury (ASIA B or better), which has significantly better prognosis than complete injury.

Investigations

ImmediateCT Spine
As soon as stableMRI Spine
ImmediateHemodynamic Monitoring
ED arrivalBaseline Bloods
On arrivalChest X-ray

MRI Findings and Prognosis

MRI FindingDescriptionPrognostic Significance
HemorrhageT1 hyperintense, T2 variablePoor prognosis - irreversible damage
Edema onlyT2 hyperintense, normal T1Better prognosis - may recover
Cord transectionComplete cord disruptionComplete injury, no recovery
Compression without signalMechanical compression, normal cordBest prognosis if decompressed

MRI Timing

MRI should not delay resuscitation or surgery in unstable patients. However, for incomplete injuries with unclear pathology, MRI within 24 hours helps guide surgical planning. Hemorrhage on MRI predicts poor outcome regardless of ASIA grade.

Management

📊 Management Algorithm
Acute spinal cord injury management algorithm flowchart
Click to expand
SCI Management Algorithm - ASIA-based decision pathway with MAP goals and surgical timingCredit: OrthoVellum

Initial Management Priorities

Immobilization:

  • Rigid cervical collar until cleared
  • Log roll precautions
  • Spinal board for transport only (pressure injury risk)

Airway and Breathing:

  • Early intubation if GCS impaired or respiratory compromise
  • C5 injury and above may need ventilatory support
  • Avoid neck extension during intubation (fiber-optic if available)

Circulation - MAP Goals:

  • Arterial line for continuous monitoring
  • Target MAP 85-90mmHg for 5-7 days
  • Vasopressors (norepinephrine first line)
  • Avoid hypotension at all costs - causes secondary injury

NO Methylprednisolone: Previously given based on NASCIS trials but now recognized as flawed evidence. Current guidelines recommend AGAINST steroids due to no proven benefit and potential harm (infection, GI bleed).

Timing of Surgery

Early Surgery (within 24 hours):

  • Recommended for incomplete SCI (ASIA B-D) with compression
  • STASCIS trial suggests benefit within 24 hours
  • Decompress and stabilize

Urgent Surgery:

  • Deteriorating neurological status
  • Unstable spine injury
  • Irreducible fracture-dislocation

Deferred Surgery:

  • Complete injury (ASIA A) - no urgency for neurological outcome
  • Medically unstable patient
  • No ongoing compression

Surgical Goals: Decompress neural elements, restore spinal alignment, and provide stability for early mobilization.

Critical Care Considerations

Respiratory:

  • F ICU admission for cervical injuries
  • May need tracheostomy if prolonged ventilation
  • Aggressive pulmonary toilet
  • Monitor for neurogenic pulmonary edema

Cardiovascular:

  • Continuous MAP monitoring
  • Vasopressor support as needed
  • Bradycardia treatment if symptomatic
  • Avoid hypothermia (impairs clotting)

DVT Prophylaxis:

  • Very high DVT/PE risk in SCI
  • LMWH + mechanical prophylaxis
  • Consider IVC filter if anticoagulation contraindicated

Pressure Injury Prevention:

  • Turn every 2 hours
  • Specialty mattress
  • Remove spinal board early

Bowel and Bladder: Indwelling catheter initially with early bowel regime (stool softeners, enemas). Transition to intermittent catheterization when stable.

Surgical Technique

Anterior Cervical Decompression and Fusion

Indications:

  • Anterior compression (disc herniation, vertebral body)
  • Corpectomy required
  • Kyphotic deformity

Technique: Position supine with head in neutral. Approach through Smith-Robinson interval (medial to SCM). Perform discectomy or corpectomy as required. Decompress spinal cord under microscope. Place structural graft or cage. Apply anterior plate. Confirm alignment on fluoroscopy.

Advantages: Direct anterior decompression, restoration of lordosis.

Risks: Recurrent laryngeal nerve, esophageal injury, dysphagia.

Posterior Cervical Decompression and Fusion

Indications:

  • Posterior compression (facet fracture, posterior mass)
  • Multi-level pathology
  • Failed anterior approach

Technique: Position prone (Mayfield head holder or Gardner-Wells tongs). Midline exposure to lateral masses. Laminectomy or laminoplasty for decompression. Place lateral mass screws (Magerl technique) or pedicle screws. Rod contouring for sagittal alignment. Decortication and bone grafting.

Advantages: Better fixation in osteoporotic bone, longer constructs.

Risks: Vertebral artery injury, wound complications.

Complications

Complications of Spinal Cord Injury

ComplicationTimeframePrevention/Management
Respiratory failureAcuteEarly intubation if C5+, pulmonary toilet
DVT/PEDays to weeksLMWH + mechanical, IVC filter if needed
Pressure ulcersDays to weeksTurn q2h, specialty mattress, early mobilization
Autonomic dysreflexiaChronic (T6+)Identify and remove noxious stimulus
Heterotopic ossificationWeeks to monthsNSAIDs prophylaxis, radiation if high risk
SpasticityChronicPhysiotherapy, baclofen, botulinum toxin

Autonomic Dysreflexia

Medical emergency in chronic SCI above T6. Caused by noxious stimulus below injury (full bladder, constipation). Presents with hypertension, bradycardia, headache, sweating. Treatment: sit upright, identify and remove trigger. May need antihypertensives if severe.

Postoperative Care

Week 1Day 0-7
Week 1-2Week 1-2
Week 2-6Week 2-6
Long-termMonths 3-12

Early Rehabilitation

Transfer to spinal rehabilitation unit as soon as medically stable. Multidisciplinary care (physio, OT, psychology, social work) significantly improves functional outcomes. Most neurological recovery occurs in first 6-12 months.

Outcomes and Prognosis

Neurological Recovery

ASIA A (Complete):

  • Less than 5% regain functional ambulation
  • Recovery plateaus within 1 year
  • Focus is on maximizing function at level of injury

ASIA B (Sensory Incomplete):

  • 50% regain some walking ability
  • Better prognosis than complete injury
  • Early surgery may improve outcomes

ASIA C (Motor Incomplete):

  • 75% improve at least one ASIA grade
  • Most will achieve some ambulation
  • Priority for early decompression

ASIA D (Good Motor):

  • 95% maintain community ambulation
  • Excellent functional prognosis

MRI Hemorrhage = Poor Prognosis

Cord hemorrhage on MRI is the strongest predictor of poor outcome, regardless of initial ASIA grade. Edema without hemorrhage has better recovery potential.

Evidence Base and Key Trials

NASCIS II Trial (National Acute Spinal Cord Injury Study)

2
Bracken et al. • NEJM (1990)
Key Findings:
  • Multicenter RCT: 487 patients with acute SCI
  • Methylprednisolone vs placebo vs naloxone
  • No primary analysis difference; benefit only in post-hoc subgroup
  • Criticized for flawed methodology and multiple post-hoc analyses
Clinical Implication: This trial is NO LONGER used to justify steroids. Current guidelines recommend AGAINST routine steroid use in SCI.
Limitation: Post-hoc analysis; significant methodological concerns.

STASCIS Trial (Surgical Timing in Acute Spinal Cord Injury Study)

2
Fehlings et al. • PLOS ONE (2012)
Key Findings:
  • Prospective cohort: 313 patients with cervical SCI
  • Early surgery (less than 24h) vs late surgery (greater than 24h)
  • Early surgery: 2x greater odds of 2+ ASIA grade improvement
  • Supports early decompression in incomplete injuries
Clinical Implication: Early decompression (less than 24 hours) improves neurological outcomes in incomplete SCI. Time matters.
Limitation: Prospective observational, not RCT; selection bias possible.

AANS/CNS Guidelines on MAP Targets

3
AANS/CNS Guidelines Committee • Neurosurgery (2013)
Key Findings:
  • Systematic review of hemodynamic management in SCI
  • MAP 85-90 mmHg for first 5-7 days recommended
  • Avoids secondary ischemic injury to spinal cord
  • ICU-level monitoring required
Clinical Implication: MAP 85-90 mmHg is standard of care for first 7 days. Norepinephrine is preferred vasopressor.
Limitation: Guideline-level evidence; no RCT specifically addressing targets.

NASCIS III Trial

2
Bracken et al. • JAMA (1997)
Key Findings:
  • 658 patients with acute SCI
  • Extended 48h methylprednisolone if started 3-8h post-injury
  • No benefit over 24h; increased complications (pneumonia, sepsis)
  • Led to abandonment of steroid protocols
Clinical Implication: Further evidence against routine steroid use. Risks outweigh any unproven benefits.
Limitation: Same methodological issues as NASCIS II.

Central Cord Syndrome Prognosis Study

3
Pouw et al. • Spine (2010)
Key Findings:
  • Systematic review of incomplete SCI recovery
  • Central cord syndrome has best prognosis of incomplete injuries
  • Upper limb function often improves significantly over 12 months
  • Lower limbs and bladder recovery variable
Clinical Implication: Central cord has favorable prognosis. Brown-Sequard even better. Anterior cord syndrome worst.
Limitation: Heterogeneous studies; reporting bias.

Exam Viva Scenarios

Practice these scenarios to excel in your viva examination

VIVA SCENARIOAdvanced

EXAMINER

"A 25-year-old male is brought to ED after a diving accident. He has no motor or sensory function below C5 level. His BP is 80/50 and heart rate is 48. How would you manage this patient?"

EXCEPTIONAL ANSWER
For this challenging scenario. This patient has a complete cervical spinal cord injury at C5 with neurogenic shock. My immediate priority is resuscitation following ATLS principles. For airway, I would prepare for early intubation given the high cervical level compromising respiratory function, with in-line stabilization. For breathing, I would assess respiratory effort and be prepared for ventilatory support. For circulation, the hypotension with bradycardia indicates neurogenic shock from loss of sympathetic tone. I would place an arterial line and target MAP 85-90mmHg using vasopressors, with norepinephrine as first line. Atropine for symptomatic bradycardia. I would obtain CT entire spine urgently and plan MRI when stable. Given this appears to be ASIA A complete injury, prognosis for neurological recovery is poor regardless of treatment timing. However, I would still stabilize the spine to facilitate rehabilitation. I would admit to ICU for MAP goals, respiratory monitoring, and DVT prophylaxis.
KEY POINTS TO SCORE
Recognize neurogenic shock: hypotension with bradycardia
MAP goal 85-90mmHg for 5-7 days
ASIA A complete injury has poor prognosis
ICU admission for MAP goals and respiratory monitoring
COMMON TRAPS
✗Confusing neurogenic shock with hypovolemic shock
✗Not recognizing the need for early intubation in high cervical injury
✗Giving methylprednisolone (not recommended)
LIKELY FOLLOW-UPS
"What is the difference between neurogenic and spinal shock?"
"Would you give methylprednisolone?"
"When would you take this patient to surgery?"
VIVA SCENARIOStandard

EXAMINER

"A 68-year-old man with known cervical spondylosis falls backwards and presents with weakness affecting his upper limbs more than lower limbs. Describe the syndrome and management."

EXCEPTIONAL ANSWER
This presentation is classic for central cord syndrome, the most common incomplete spinal cord injury pattern. It typically occurs in elderly patients with pre-existing cervical stenosis following a hyperextension mechanism. The upper limbs are affected more than lower limbs because the corticospinal tracts are organized with cervical fibers centrally and sacral fibers peripherally. My assessment would confirm ASIA grade through formal motor and sensory examination including sacral sparing. Imaging would include CT to assess bony injury and MRI to evaluate cord signal, compression, and disc pathology. Management in the acute phase includes MAP goals of 85-90mmHg and admission for neurological observation. Surgical timing is somewhat controversial in central cord syndrome. Many recommend non-operative management initially as spontaneous recovery can be good. However, if there is persistent compression on MRI with ongoing deficit, surgical decompression is indicated. Prognosis is generally good, with many patients regaining ambulatory function, though fine hand function recovery may be incomplete.
KEY POINTS TO SCORE
Central cord syndrome: upper limbs worse than lower limbs
Most common incomplete SCI pattern
Hyperextension injury in elderly with cervical stenosis
Best prognosis of incomplete syndromes
COMMON TRAPS
✗Rushing to surgery too early - spontaneous recovery can occur
✗Missing the diagnosis by not examining upper limbs carefully
✗Not obtaining MRI to assess cord compression
LIKELY FOLLOW-UPS
"What are the prognostic factors in central cord syndrome?"
"When would you recommend surgery vs conservative management?"
"What other incomplete syndromes should you know?"
VIVA SCENARIOAdvanced

EXAMINER

"Discuss the evidence for and against methylprednisolone in acute spinal cord injury."

EXCEPTIONAL ANSWER
This is a controversial topic that has evolved significantly. The NASCIS II trial in 1990 compared methylprednisolone to placebo and initially showed no benefit in the primary analysis. However, post-hoc subgroup analysis suggested benefit if given within 8 hours. This led to widespread adoption of high-dose methylprednisolone protocol. The NASCIS III trial in 1997 compared 24 versus 48-hour regimens and again relied on post-hoc analysis. These trials have been heavily criticized for methodological flaws, including post-hoc analysis, lack of functional outcomes, and ignoring complications. The complications of high-dose steroids include increased infection rates, gastrointestinal bleeding, and hyperglycemia. Current guidelines from AANS/CNS and AOSpine recommend AGAINST routine methylprednisolone use in SCI. Some guidelines allow for consideration as an option with informed consent about risks and uncertain benefit. My practice is not to use steroids, focusing instead on MAP goals, early decompression for incomplete injuries, and preventing secondary injury.
KEY POINTS TO SCORE
NASCIS II/III trials have methodological flaws
No proven benefit, only post-hoc analysis
Current guidelines recommend AGAINST steroids
Focus on MAP goals and early decompression instead
COMMON TRAPS
✗Citing NASCIS as evidence for steroids - the trials are flawed
✗Not knowing the complications of high-dose steroids
✗Not having a clear answer on current recommendations
LIKELY FOLLOW-UPS
"What are the current recommendations for acute SCI management?"
"How would you counsel a patient's family asking about steroids?"

MCQ Practice Points

ASIA A Definition Question

Q: What defines an ASIA A spinal cord injury? A: Complete injury with no motor or sensory function below the level, including S4-S5. Less than 5% will regain functional ambulation regardless of treatment timing.

Sacral Sparing Question

Q: What is the clinical significance of sacral sparing after spinal cord injury? A: Sacral sparing indicates incomplete injury (ASIA B or better). Check perianal sensation, deep anal pressure, and voluntary anal contraction. Prognosis is significantly better than complete injury.

Neurogenic vs Spinal Shock Question

Q: What is the difference between neurogenic shock and spinal shock? A: Neurogenic shock = cardiovascular (hypotension + bradycardia from sympathetic loss). Spinal shock = neurological (areflexia and flaccidity below level). They often coexist but are distinct entities.

MAP Goals Question

Q: What is the target MAP in acute spinal cord injury and for how long? A: MAP 85-90 mmHg for 5-7 days to optimize spinal cord perfusion and prevent secondary ischemic injury. Norepinephrine is preferred vasopressor.

Methylprednisolone Question

Q: What is the current recommendation regarding methylprednisolone in acute SCI? A: NOT recommended. NASCIS trials were methodologically flawed with post-hoc analysis only. Current AANS/CNS guidelines recommend against routine steroid use.

Incomplete Syndrome Prognosis Question

Q: Which incomplete SCI syndrome has the best and worst prognosis? A: Best: Brown-Sequard syndrome (90% ambulatory). Worst: Anterior cord syndrome (only 10-20% recovery; only dorsal columns spared). Central cord has intermediate but favorable prognosis.

Australian Context

Epidemiology

  • 350-400 new traumatic SCIs per year in Australia
  • Main causes: transport (50%), falls (30%)
  • Increasing proportion of elderly patients
  • Indigenous Australians overrepresented

Healthcare System

  • State spinal cord services (Austin Hospital Victoria, POWH NSW)
  • Retrieval services for early transfer
  • NDIS supports long-term care and equipment
  • Spinal Cord Injury Network Australia

Transfer Considerations

Early transfer to specialized spinal cord center improves outcomes. Contact retrieval services early for cervical and complete injuries. Document neurological examination clearly for handover.

SPINAL CORD INJURY

High-Yield Exam Summary

ASIA Classification

  • •A = Complete (no motor/sensory S4-S5)
  • •B = Sensory only incomplete
  • •C = Motor incomplete (less than grade 3)
  • •D = Motor incomplete (grade 3+)
  • •E = Normal

Neurogenic vs Spinal Shock

  • •Neurogenic: Hypotension + bradycardia (cardiovascular)
  • •Spinal: Areflexia below level (neurological)
  • •Spinal shock ends when bulbocavernosus returns
  • •Neurogenic shock occurs with T6 and above injuries

Acute Management

  • •MAP 85-90mmHg for 5-7 days
  • •NO methylprednisolone (NASCIS flawed)
  • •Early surgery within 24h for incomplete SCI
  • •DVT prophylaxis essential

Incomplete Syndromes

  • •Central cord: UL worse than LL, best prognosis
  • •Brown-Sequard: Hemisection, good prognosis
  • •Anterior cord: Worst prognosis (dorsal spared)
  • •Posterior cord: Rare, proprioception loss

Prognosis by ASIA Grade

  • •ASIA A: Less than 5% functional ambulation
  • •ASIA B: 50% regain walking
  • •ASIA C: 75% improve one grade
  • •ASIA D: 95% maintain community walking
Quick Stats
Reading Time78 min
Related Topics

Acetabular Fractures

Acromioclavicular Joint Injuries

Acute Compartment Syndrome

Ankle Fractures